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HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers
Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival and proliferation in model systems. The common assumption is that these effects are mediated through regulation of heat-shock protein (HSP) expression. However, the tra...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3438889/ https://ncbi.nlm.nih.gov/pubmed/22863008 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.06.031 |
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