Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome

High-dose ionizing radiation induces severe DNA damage in the epithelial stem cells in small intestinal crypts and causes gastrointestinal syndrome (GIS). Although the tumour suppressor p53 is a primary factor inducing death of crypt cells with DNA damage, its essential role in maintaining genome st...

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Main Authors: Takemura, Naoki, Kawasaki, Takumi, Kunisawa, Jun, Sato, Shintaro, Lamichhane, Aayam, Kobiyama, Kouji, Aoshi, Taiki, Ito, Junichi, Mizuguchi, Kenji, Karuppuchamy, Thangaraj, Matsunaga, Kouta, Miyatake, Shoichiro, Mori, Nobuko, Tsujimura, Tohru, Satoh, Takashi, Kumagai, Yutaro, Kawai, Taro, Standley, Daron M., Ishii, Ken J., Kiyono, Hiroshi, Akira, Shizuo, Uematsu, Satoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959210/
https://ncbi.nlm.nih.gov/pubmed/24637670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4492
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