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BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways

The fate of pluripotent stem cells is tightly controlled during early embryonic development. Both the derivation and the maintenance of embryonic stem cells (ES cells) in vitro depend on feeder cell-derived growth factors that are largely unidentified. To dissect the mechanisms governing pluripotenc...

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Библиографические подробности
Главные авторы: Qi, Xiaoxia, Li, Teng-Guo, Hao, Jing, Hu, Jie, Wang, Jing, Simmons, Holly, Miura, Shigeto, Mishina, Yuji, Zhao, Guang-Quan
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2004
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC395917/
https://ncbi.nlm.nih.gov/pubmed/15075392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401367101
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