Structural elements responsible for conversion of streptavidin to a pseudoenzyme

Avidin enhances the hydrolysis of biotinyl p-nitrophenyl ester (BNP) under mild alkaline conditions, whereas streptavidin prevents hydrolysis of BNP up to pH 12. Recently, we imposed hydrolytic activity on streptavidin by rational mutagenesis, based on the molecular elements responsible for the hydr...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Eisenberg-Domovich, Yael, Pazy, Yael, Nir, Orit, Raboy, Bilha, Bayer, Edward A., Wilchek, Meir, Livnah, Oded
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2004
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395898/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15079055/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0308541101
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