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RhoBTB2 is a substrate of the mammalian Cul3 ubiquitin ligase complex

Rhobtb2 is a candidate tumor suppressor located on human chromosome 8p21, a region commonly deleted in cancer. Rhobtb2 is homozygously deleted in 3.5% of primary breast cancers, and gene expression is ablated in ∼50% of breast and lung cancer cell lines. RhoBTB2 is an 83-kD, atypical Rho GTPase of u...

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Bibliografske podrobnosti
izdano v:Genes Dev
Main Authors: Wilkins, Andrew, Ping, Qinggong, Carpenter, Christopher L.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2004
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395845/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15107402/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1177904
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