Effects of Selective and Non-Selective Glucocorticoid Receptor II Antagonists on Rapid-Onset Diabetes in Young Rats

The blockade of glucocorticoid (GC) action through antagonism of the glucocorticoid receptor II (GRII) has been used to minimize the undesirable effects of chronically elevated GC levels. Mifepristone (RU486) is known to competitively block GRII action, but not exclusively, as it antagonizes the pro...

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Main Authors: Beaudry, Jacqueline L., Dunford, Emily C., Teich, Trevor, Zaharieva, Dessi, Hunt, Hazel, Belanoff, Joseph K., Riddell, Michael C.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958344/
https://ncbi.nlm.nih.gov/pubmed/24642683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091248
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