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Effects of Selective and Non-Selective Glucocorticoid Receptor II Antagonists on Rapid-Onset Diabetes in Young Rats

The blockade of glucocorticoid (GC) action through antagonism of the glucocorticoid receptor II (GRII) has been used to minimize the undesirable effects of chronically elevated GC levels. Mifepristone (RU486) is known to competitively block GRII action, but not exclusively, as it antagonizes the pro...

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Autors principals: Beaudry, Jacqueline L., Dunford, Emily C., Teich, Trevor, Zaharieva, Dessi, Hunt, Hazel, Belanoff, Joseph K., Riddell, Michael C.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958344/
https://ncbi.nlm.nih.gov/pubmed/24642683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091248
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