Microvesicular Caspase-1 Mediates Lymphocyte Apoptosis in Sepsis

OBJECTIVE: Immune dysregulation during sepsis is poorly understood, however, lymphocyte apoptosis has been shown to correlate with poor outcomes in septic patients. The inflammasome, a molecular complex which includes caspase-1, is essential to the innate immune response to infection and also import...

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Main Authors: Exline, Matthew C., Justiniano, Steven, Hollyfield, Jennifer L., Berhe, Freweine, Besecker, Beth Y., Das, Srabani, Wewers, Mark D., Sarkar, Anasuya
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958341/
https://ncbi.nlm.nih.gov/pubmed/24643116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090968
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