Caspase-1 Regulates Escherichia coli Sepsis and Splenic B Cell Apoptosis Independently of Interleukin-1β and Interleukin-18

Rationale: Caspase-1 processes interleukin 1β (IL-1β) and IL-18 but may also contribute to apoptosis. In this context, caspase-1 knockout mice have been shown to be protected from endotoxin-induced mortality, whereas IL-1β knockout mice are not protected. Objectives: We therefore sought to delineate...

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Detalhes bibliográficos
Main Authors: Sarkar, Anasuya, Hall, Mark W., Exline, Matthew, Hart, Judy, Knatz, Nina, Gatson, Na Tosha, Wewers, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2006
Assuntos:
D. Critical Care
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648100/
https://ncbi.nlm.nih.gov/pubmed/16908867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200604-546OC
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