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Pathogenic Mutations within the Hydrophobic Domain of the Prion Protein Lead to the Formation of Protease-Sensitive Prion Species with Increased Lethality

Prion diseases are a group of fatal and incurable neurodegenerative diseases affecting both humans and animals. The principal mechanism of these diseases involves the misfolding the host-encoded cellular prion protein, PrP(C), into the disease-associated isoform, PrP(Sc). Familial forms of human pri...

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Detalhes bibliográficos
Main Authors: Coleman, Bradley M., Harrison, Christopher F., Guo, Belinda, Masters, Colin L., Barnham, Kevin J., Lawson, Victoria A., Hill, Andrew F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958101/
https://ncbi.nlm.nih.gov/pubmed/24352465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02720-13
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