Mechanism of Neutralization of Herpes Simplex Virus by Antibodies Directed at the Fusion Domain of Glycoprotein B

Glycoprotein B (gB), the fusogen of herpes simplex virus (HSV), is a class III fusion protein with a trimeric ectodomain of known structure for the postfusion state. Seen by negative-staining electron microscopy, it presents as a rod with three lobes (base, middle, and crown). gB has four functional...

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Main Authors: Cairns, Tina M., Fontana, Juan, Huang, Zhen-Yu, Whitbeck, J. Charles, Atanasiu, Doina, Rao, Samhita, Shelly, Spencer S., Lou, Huan, Ponce de Leon, Manuel, Steven, Alasdair C., Eisenberg, Roselyn J., Cohen, Gary H.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2014
主題:
Structure and Assembly
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958082/
https://ncbi.nlm.nih.gov/pubmed/24352457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03200-13
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