Antibody-Induced Conformational Changes in Herpes Simplex Virus Glycoprotein gD Reveal New Targets for Virus Neutralization

As the receptor-binding protein of herpes simplex virus (HSV), gD plays an essential role in virus entry. In its native state, the last 56 amino acids of the ectodomain C terminus (C-term) occlude binding to its receptors, herpesvirus entry mediator (HVEM) and nectin-1. Although it is clear that mov...

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Main Authors: Lazear, Eric, Whitbeck, J. Charles, Ponce-de-Leon, Manuel, Cairns, Tina M., Willis, Sharon H., Zuo, Yi, Krummenacher, Claude, Cohen, Gary H., Eisenberg, Roselyn J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3264331/
https://ncbi.nlm.nih.gov/pubmed/22130533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06480-11
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