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c-Jun N-Terminal Kinase 1/c-Jun Activation of the p53/MicroRNA 34a/Sirtuin 1 Pathway Contributes to Apoptosis Induced by Deoxycholic Acid in Rat Liver

MicroRNAs (miRs) are increasingly associated with metabolic liver diseases. We have shown that ursodeoxycholic acid, a hydrophilic bile acid, counteracts the miR-34a/sirtuin 1 (SIRT1)/p53 pathway, activated in the liver of nonalcoholic steatohepatitis (NASH) patients. In contrast, hydrophobic bile a...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Ferreira, Duarte M. S., Afonso, Marta B., Rodrigues, Pedro M., Simão, André L., Pereira, Diane M., Borralho, Pedro M., Rodrigues, Cecília M. P., Castro, Rui E.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology 2014
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958031/
https://ncbi.nlm.nih.gov/pubmed/24421392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00420-13
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