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Sirtuin 1 (SIRT1) Protein Degradation in Response to Persistent c-Jun N-terminal Kinase 1 (JNK1) Activation Contributes to Hepatic Steatosis in Obesity

SIRT1 is involved in the pathogenesis of obesity, diabetes, and aging. However, it is not clear how SIRT1 activity is regulated by intracellular kinases in cells. In this study, we investigated SIRT1 phosphorylation and protein degradation in response to JNK1 activation in obese mice. Mouse SIRT1 is...

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Main Authors: Gao, Zhanguo, Zhang, Jin, Kheterpal, Indu, Kennedy, Norm, Davis, Roger J., Ye, Jianping
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121368/
https://ncbi.nlm.nih.gov/pubmed/21540183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.228874
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