In Vitro Characterization of MK-1439, a Novel HIV-1 Nonnucleoside Reverse Transcriptase Inhibitor

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are a mainstay of therapy for treating human immunodeficiency type 1 virus (HIV-1)-infected patients. MK-1439 is a novel NNRTI with a 50% inhibitory concentration (IC(50)) of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C re...

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Autori principali: Lai, Ming-Tain, Feng, Meizhen, Falgueyret, Jean-Pierre, Tawa, Paul, Witmer, Marc, DiStefano, Daniel, Li, Yuan, Burch, Jason, Sachs, Nancy, Lu, Meiqing, Cauchon, Elizabeth, Campeau, Louis-Charles, Grobler, Jay, Yan, Youwei, Ducharme, Yves, Côté, Bernard, Asante-Appiah, Ernest, Hazuda, Daria J., Miller, Michael D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957832/
https://ncbi.nlm.nih.gov/pubmed/24379202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02403-13
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