Antiviral Activity and In Vitro Mutation Development Pathways of MK-6186, a Novel Nonnucleoside Reverse Transcriptase Inhibitor

MK-6186 is a novel nonnucleoside reverse transcriptase inhibitor (NNRTI) which displays subnanomolar potency against wild-type (WT) virus and the two most prevalent NNRTI-resistant RT mutants (K103N and Y181C) in biochemical assays. In addition, it showed excellent antiviral potency against K103N an...

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Detalhes bibliográficos
Main Authors: Lu, Meiqing, Felock, Peter J., Munshi, Vandna, Hrin, Renee C., Wang, Ying-Jie, Yan, Youwei, Munshi, Sanjeev, McGaughey, Georgia B., Gomez, Robert, Anthony, Neville J., Williams, Theresa M., Grobler, Jay A., Hazuda, Daria J., McKenna, Philip M., Miller, Michael D., Lai, Ming-Tain
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370804/
https://ncbi.nlm.nih.gov/pubmed/22391531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00102-12
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