Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis

Mammalian kidney organogenesis involves reciprocal epithelial-mesenchymal interactions that drive iterative cycles of nephron formation. Recent studies have demonstrated that the Six2 transcription factor acts cell autonomously to maintain nephron progenitor cells, whereas canonical Wnt signaling in...

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Bibliographic Details
Main Authors: Xu, Jingyue, Liu, Han, Park, Joo-Seop, Lan, Yu, Jiang, Rulang
Format: Artigo
Language:Inglês
Published: Company of Biologists 2014
Subjects:
Stem Cells and Regeneration
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957368/
https://ncbi.nlm.nih.gov/pubmed/24598167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.103283
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