H2A.Z depletion impairs proliferation and viability but not DNA double-strand breaks repair in human immortalized and tumoral cell lines

In mammalian cells, DNA double-strand breaks (DSB) can be repaired by 2 main pathways, homologous recombination (HR) and non-homologous end joining (NHEJ). To give access to DNA damage to the repair machinery the chromatin structure needs to be relaxed, and chromatin modifications play major roles i...

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Main Authors: Taty-Taty, Gemael-Cedrick, Courilleau, Celine, Quaranta, Muriel, Carayon, Alexandre, Chailleux, Catherine, Aymard, François, Trouche, Didier, Canitrot, Yvan
格式: Artigo
語言:Inglês
出版: Landes Bioscience 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956535/
https://ncbi.nlm.nih.gov/pubmed/24240188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.27143
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