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Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels

We identified a mutation in the Diet1 gene in a mouse strain that is resistant to hyperlipidemia and atherosclerosis. Diet1 encodes a 236 kD protein consisting of tandem low density lipoprotein receptor and MAM (meprin-A5-protein tyrosine phosphatase mu) domains, and is expressed in enterocytes of t...

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書誌詳細
主要な著者: Vergnes, Laurent, Lee, Jessica M., Chin, Robert G., Auwerx, Johan, Reue, Karen
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956443/
https://ncbi.nlm.nih.gov/pubmed/23747249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.04.007
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