Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants

Diet1 modulates intestinal production of the hormone, fibroblast growth factor (FGF)15, which signals in liver to regulate bile acid synthesis. C57BL/6ByJ mice with a spontaneous Diet1-null mutation are resistant to hypercholesterolemia compared with wild-type C57BL/6J mice through enhanced choleste...

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Bibliographic Details
Published in:J Lipid Res
Main Authors: Lee, Jessica M., Ong, Jessica R., Vergnes, Laurent, de Aguiar Vallim, Thomas Q., Nolan, Jonathan, Cantor, Rita M., Walters, Julian R. F., Reue, Karen
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2018
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832924/
https://ncbi.nlm.nih.gov/pubmed/29295820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M078279
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