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Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore
Disease associated with Clostridium difficile infection is caused by the actions of the homologous toxins TcdA and TcdB on colonic epithelial cells. Binding to target cells triggers toxin internalization into acidified vesicles, whereupon cryptic segments from within the 1,050-aa translocation domai...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3956163/ https://ncbi.nlm.nih.gov/pubmed/24567384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400680111 |
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