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Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis
Pbx-regulating protein-1 (Prep1) is a tumor suppressor, whereas myeloid ecotropic viral integration site-1 (Meis1) is an oncogene. We show that, to perform these activities in mouse embryonic fibroblasts, both proteins competitively heterodimerize with pre–B-cell leukemia homeobox-1 (Pbx1). Meis1 al...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3956142/ https://ncbi.nlm.nih.gov/pubmed/24578510 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321200111 |
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