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New Insights into Cooperative Binding of Homeodomain Transcription Factors PREP1 and PBX1 to DNA

PREP1 and PBX1 are homeodomain (HD) transcription factors that play crucial roles in embryonic development. Here, we present the first biophysical characterization of a PREP1 HD, and the NMR spectroscopic study of its DNA binding pocket. The data show that residues flanking the HD participate in DNA...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Zucchelli, Chiara, Ferrari, Elena, Blasi, Francesco, Musco, Giovanna, Bruckmann, Chiara
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240567/
https://ncbi.nlm.nih.gov/pubmed/28094776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40665
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