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New Insights into Cooperative Binding of Homeodomain Transcription Factors PREP1 and PBX1 to DNA
PREP1 and PBX1 are homeodomain (HD) transcription factors that play crucial roles in embryonic development. Here, we present the first biophysical characterization of a PREP1 HD, and the NMR spectroscopic study of its DNA binding pocket. The data show that residues flanking the HD participate in DNA...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5240567/ https://ncbi.nlm.nih.gov/pubmed/28094776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40665 |
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