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Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis

Pbx-regulating protein-1 (Prep1) is a tumor suppressor, whereas myeloid ecotropic viral integration site-1 (Meis1) is an oncogene. We show that, to perform these activities in mouse embryonic fibroblasts, both proteins competitively heterodimerize with pre–B-cell leukemia homeobox-1 (Pbx1). Meis1 al...

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書誌詳細
主要な著者: Dardaei, Leila, Longobardi, Elena, Blasi, Francesco
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3956142/
https://ncbi.nlm.nih.gov/pubmed/24578510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321200111
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