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Posttranscriptional Silencing of Effector Cytokine mRNA Underlies the Anergic Phenotype of Self-Reactive T Cells

Self-reactive T cell clones that escape negative selection are either deleted or rendered functionally unresponsive (anergic), thus preventing them from propagating host tissue damage. By using an in vivo model, we investigated molecular mechanisms for T cell tolerance, finding that despite a charac...

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Detalhes bibliográficos
Main Authors: Villarino, Alejandro V., Katzman, Shoshana D., Gallo, Eugenio, Miller, Omer, Jiang, Shuwei, McManus, Michael T., Abbas, Abul K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3955755/
https://ncbi.nlm.nih.gov/pubmed/21236706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2010.12.014
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