Effects of local mRNA structure on posttranscriptional gene silencing

Antisense oligodeoxynucleotides (AONs) and short interfering RNAs (siRNAs) effect posttranscriptional gene silencing (PTGS) by hybridizing to an mRNA and then directing its cleavage. To understand the constraints that mRNA structure imposes on AON- vs. siRNA-mediated PTGS, AON- and siRNA-mediated cl...

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Hlavní autoři: Rudnick, Stephen I., Swaminathan, Jyothishmathi, Sumaroka, Marina, Liebhaber, Stephen, Gewirtz, Alan M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544532/
https://ncbi.nlm.nih.gov/pubmed/18784366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805781105
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