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Effects of local mRNA structure on posttranscriptional gene silencing

Antisense oligodeoxynucleotides (AONs) and short interfering RNAs (siRNAs) effect posttranscriptional gene silencing (PTGS) by hybridizing to an mRNA and then directing its cleavage. To understand the constraints that mRNA structure imposes on AON- vs. siRNA-mediated PTGS, AON- and siRNA-mediated cl...

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Detaylı Bibliyografya
Asıl Yazarlar: Rudnick, Stephen I., Swaminathan, Jyothishmathi, Sumaroka, Marina, Liebhaber, Stephen, Gewirtz, Alan M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2008
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2544532/
https://ncbi.nlm.nih.gov/pubmed/18784366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805781105
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