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KRAS: feeding pancreatic cancer proliferation

Oncogenic KRAS mutation is the signature genetic event in the progression and growth of pancreatic ductal adenocarcinoma (PDAC), an almost universally fatal disease. Although it has been appreciated for some time that nearly 95% of PDAC harbor mutationally activated KRAS, to date no effective treatm...

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Detalhes bibliográficos
Main Authors: Bryant, Kirsten L., Mancias, Joseph D., Kimmelman, Alec C., Der, Channing J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3955735/
https://ncbi.nlm.nih.gov/pubmed/24388967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2013.12.004
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