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KRAS: feeding pancreatic cancer proliferation

Oncogenic KRAS mutation is the signature genetic event in the progression and growth of pancreatic ductal adenocarcinoma (PDAC), an almost universally fatal disease. Although it has been appreciated for some time that nearly 95% of PDAC harbor mutationally activated KRAS, to date no effective treatm...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Bryant, Kirsten L., Mancias, Joseph D., Kimmelman, Alec C., Der, Channing J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3955735/
https://ncbi.nlm.nih.gov/pubmed/24388967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tibs.2013.12.004
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