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Rapid profiling of protein kinase inhibitors by quantitative proteomics
The ability to determine structure-activity relationships (SAR) and identify cellular targets from cell lysates and tissues is of great utility for kinase inhibitor drug discovery. We describe a streamlined mass spectrometry-based chemoproteomics workflow to examine the SAR and target profiles of a...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3955727/ https://ncbi.nlm.nih.gov/pubmed/24648882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3MD00315A |
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