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From Arrest to Escape: HIV-1 Vpr Cuts a Deal
HIV Vpr induces a cell-cycle arrest at the G2-to-M transition through a poorly understood mechanism. In a recent issue of Cell, Laguette et al. (2014) demonstrate that untimely activation of the structure-specific endonuclease regulator SLX4 complex by Vpr promotes G2/M arrest and escape from innate...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3955185/ https://ncbi.nlm.nih.gov/pubmed/24528857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2014.01.012 |
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