A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

Benzer Materyaller

• Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.
  Yazar:: Traenckner, E B, ve diğerleri
  Baskı/Yayın Bilgisi: (1995)
• Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
  Yazar:: Alkalay, I, ve diğerleri
  Baskı/Yayın Bilgisi: (1995)
• Regulation of tumor necrosis factor alpha transcription in macrophages: involvement of four kappa B-like motifs and of constitutive and inducible forms of NF-kappa B.
  Yazar:: Collart, M A, ve diğerleri
  Baskı/Yayın Bilgisi: (1990)
• Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B.
  Yazar:: Lin, Y C, ve diğerleri
  Baskı/Yayın Bilgisi: (1995)
• Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors.
  Yazar:: Finco, T S, ve diğerleri
  Baskı/Yayın Bilgisi: (1994)