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A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

Activation of the inducible transcription factor NF-kappa B involves removal of the inhibitory subunit I kappa B-alpha from a latent cytoplasmic complex. It has been reported that I kappa B-alpha is subject to both phosphorylation and proteolysis in the process of NF-kappa B activation. In this stud...

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Détails bibliographiques
Publié dans:EMBO J
Auteurs principaux: Traenckner, E B, Wilk, S, Baeuerle, P A
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 1994
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395500/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7957109/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06878.x
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