A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B.

Activation of the inducible transcription factor NF-kappa B involves removal of the inhibitory subunit I kappa B-alpha from a latent cytoplasmic complex. It has been reported that I kappa B-alpha is subject to both phosphorylation and proteolysis in the process of NF-kappa B activation. In this stud...

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izdano v:	EMBO J
Principais autores:	Traenckner, E B, Wilk, S, Baeuerle, P A
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Publishing Group 1994
Teme:	Research Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC395500/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7957109/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1994.tb06878.x
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