The Versatile Nature of the 6-Aminoquinolone Scaffold: Identification of Submicromolar Hepatitis C Virus NS5B Inhibitors

We have previously reported that the 6-aminoquinolone chemotype is a privileged scaffold to obtain antibacterial and antiviral agents. Herein we describe the design, synthesis, enzymatic and cellular characterization of new 6-aminoquinolone derivatives as potent inhibitors of NS5B polymerase, an att...

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Detalhes bibliográficos
Main Authors: Manfroni, Giuseppe, Cannalire, Rolando, Barreca, Maria Letizia, Kaushik-Basu, Neerja, Leyssen, Pieter, Winquist, Johan, Iraci, Nunzio, Manvar, Dinesh, Paeshuyse, Jan, Guhamazumder, Rupa, Basu, Amartya, Sabatini, Stefano, Tabarrini, Oriana, Danielson, U. Helena, Neyts, Johan, Cecchetti, Violetta
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954902/
https://ncbi.nlm.nih.gov/pubmed/24131104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401362f
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