New Pyrazolobenzothiazine Derivatives as Hepatitis C Virus NS5B Polymerase Palm Site I Inhibitors

[Image: see text] We have previously identified the pyrazolobenzothiazine scaffold as a promising chemotype against hepatitis C virus (HCV) NS5B polymerase, a validated and promising anti-HCV target. Herein we describe the design, synthesis, enzymatic, and cellular characterization of new pyrazolobe...

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Detalhes bibliográficos
Main Authors: Manfroni, Giuseppe, Manvar, Dinesh, Barreca, Maria Letizia, Kaushik-Basu, Neerja, Leyssen, Pieter, Paeshuyse, Jan, Cannalire, Rolando, Iraci, Nunzio, Basu, Amartya, Chudaev, Maxim, Zamperini, Claudio, Dreassi, Elena, Sabatini, Stefano, Tabarrini, Oriana, Neyts, Johan, Cecchetti, Violetta
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4203399/
https://ncbi.nlm.nih.gov/pubmed/24654886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401688h
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