Structure-based discovery of pyrazolobenzothiazine derivatives as inhibitors of hepatitis C virus replication

The NS5B RNA-dependent RNA polymerase is an attractive target for the development of novel and selective inhibitors of hepatitis C virus replication. In order to identify novel structural hits as anti-HCV agents, we performed structure-based virtual screening of our in-house library followed by rati...

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Detalhes bibliográficos
Main Authors: Barreca, Maria Letizia, Manfroni, Giuseppe, Leyssen, Pieter, Winquist, Johan, Kaushik-Basu, Neerja, Paeshuyse, Jan, Krishnan, Ramalingam, Iraci, Nunzio, Sabatini, Stefano, Tabarrini, Oriana, Basu, Amartya, Danielson, U. Helena, Neyts, Johan, Cecchetti, Violetta
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627225/
https://ncbi.nlm.nih.gov/pubmed/23409936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301643a
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