Cellular Inhibitor of Apoptosis (cIAP)-Mediated Ubiquitination of Phosphofurin Acidic Cluster Sorting Protein 2 (PACS-2) Negatively Regulates Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Cytotoxicity

Lysosomal membrane permeabilization is an essential step in TRAIL-induced apoptosis of liver cancer cell lines. TRAIL-induced lysosomal membrane permeabilization is mediated by the multifunctional sorting protein PACS-2 and repressed by the E3 ligases cIAP-1 and cIAP-2. Despite the opposing roles fo...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Guicciardi, Maria Eugenia, Werneburg, Nathan W., Bronk, Steven F., Franke, Adrian, Yagita, Hideo, Thomas, Gary, Gores, Gregory J.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2014
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954888/
https://ncbi.nlm.nih.gov/pubmed/24633224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092124
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы