Cellular Inhibitor of Apoptosis (cIAP)-Mediated Ubiquitination of Phosphofurin Acidic Cluster Sorting Protein 2 (PACS-2) Negatively Regulates Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Cytotoxicity

Lysosomal membrane permeabilization is an essential step in TRAIL-induced apoptosis of liver cancer cell lines. TRAIL-induced lysosomal membrane permeabilization is mediated by the multifunctional sorting protein PACS-2 and repressed by the E3 ligases cIAP-1 and cIAP-2. Despite the opposing roles fo...

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Detalles Bibliográficos
Main Authors: Guicciardi, Maria Eugenia, Werneburg, Nathan W., Bronk, Steven F., Franke, Adrian, Yagita, Hideo, Thomas, Gary, Gores, Gregory J.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954888/
https://ncbi.nlm.nih.gov/pubmed/24633224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092124
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