HPLC METHOD DEVELOPMENT, VALIDATION AND IMPURITY CHARACTERIZATION FOR AN ANTITUMOR HSP90 INHIBITOR -- PU-H71 (NSC 750424)

An HPLC method for the assay of the heat shock protein 90 inhibitor, PU-H71 (NSC 750424), has been developed and validated. The stress testing of PU-H71 was carried out in accordance with ICH guidelines Q1A (R2) under aqueous, acidic, alkaline, oxidative, thermolytic and photolytic conditions. The s...

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Detalhes bibliográficos
Main Authors: Liu, Mingtao, Wang, Jennie, Wu, Xiaogang, Wang, Euphemia, Baptista, Diego, Scott, Brendan, Liu, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954645/
https://ncbi.nlm.nih.gov/pubmed/24252723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2013.10.021
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