CHARACTERIZATION, HPLC METHOD DEVELOPMENT AND IMPURITY IDENTIFICATION FOR 3,4,3-LI(1,2-HOPO), A POTENT ACTINIDE CHELATOR FOR RADIONUCLIDE DECORPORATION

3,4,3-LI(1,2-HOPO), 1,5,10,14-tetra(1-hydroxy-2-pyridon-6-oyl)-1,5,10,14-tetraazatetradecane), is a potent octadentate chelator of actinides. It is being developed as a decorporation treatment for internal contamination with radionuclides. Conventional HPLC methods exhibited speciation peaks and bri...

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Bibliographic Details
Published in:J Pharm Biomed Anal
Main Authors: Liu, Mingtao, Wang, Jennie, Wu, Xiaogang, Wang, Euphemia, Abergel, Rebecca J., Shuh, David K., Raymond, Kenneth N., Liu, Paul
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4314361/
https://ncbi.nlm.nih.gov/pubmed/25459944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2014.10.015
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