Stable triple helices formed by oligonucleotide N3'-->P5' phosphoramidates inhibit transcription elongation.

Oligonucleotide analogs with N3'-->P5' phosphoramidate linkages bind to the major groove of double-helical DNA at specific oligopurine.oligopyrimidine sequences. These triple-helical complexes are much more stable than those formed by oligonucleotides with natural phosphodiester linkage...

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Bibliografske podrobnosti
Main Authors: Escudé, C, Giovannangeli, C, Sun, J S, Lloyd, D H, Chen, J K, Gryaznov, S M, Garestier, T, Hélène, C
Format: Artigo
Jezik:Inglês
Izdano: 1996
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC39543/
https://ncbi.nlm.nih.gov/pubmed/8633072
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