Stable triple helices formed by oligonucleotide N3'-->P5' phosphoramidates inhibit transcription elongation.
Oligonucleotide analogs with N3'-->P5' phosphoramidate linkages bind to the major groove of double-helical DNA at specific oligopurine.oligopyrimidine sequences. These triple-helical complexes are much more stable than those formed by oligonucleotides with natural phosphodiester linkages. Oligonucle...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1996
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39543/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8633072/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.9.4365 |
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