Stable triple helices formed by oligonucleotide N3'-->P5' phosphoramidates inhibit transcription elongation.

Oligonucleotide analogs with N3'-->P5' phosphoramidate linkages bind to the major groove of double-helical DNA at specific oligopurine.oligopyrimidine sequences. These triple-helical complexes are much more stable than those formed by oligonucleotides with natural phosphodiester linkages. Oligonucle...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Escudé, C, Giovannangeli, C, Sun, J S, Lloyd, D H, Chen, J K, Gryaznov, S M, Garestier, T, Hélène, C
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1996
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39543/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8633072/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.9.4365
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