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Ubiquibodies, Synthetic E3 Ubiquitin Ligases Endowed with Unnatural Substrate Specificity for Targeted Protein Silencing

The ubiquitin-proteasome pathway (UPP) is the main route of protein degradation in eukaryotic cells and is a common mechanism through which numerous cellular pathways are regulated. To date, several reverse genetics techniques have been reported that harness the power of the UPP for selectively redu...

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Autori principali: Portnoff, Alyse D., Stephens, Erin A., Varner, Jeffrey D., DeLisa, Matthew P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953296/
https://ncbi.nlm.nih.gov/pubmed/24474696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.544825
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