Discrimination of Potent Inhibitors of Toxoplasma gondii Enoyl-Acyl Carrier Protein Reductase by Thermal Shift Assay

Many microbial pathogens rely on a type II fatty acid synthesis (FASII) pathway which is distinct from the type I pathway found in humans. Enoyl-Acyl Carrier Protein Reductase (ENR) is an essential FASII pathway enzyme and the target of a number of antimicrobial drug discovery efforts. The biocide t...

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Autors principals: Afanador, Gustavo A., Muench, Stephen P., McPhillie, Martin, Fomovska, Alina, Schön, Arne, Zhou, Ying, Cheng, Gang, Stec, Jozef, Freundlich, Joel S., Shieh, Hong-Ming, Anderson, John W., Jacobus, David P., Fidock, David A., Kozikowski, Alan P., Fishwick, Colin W., Rice, David W., Freire, Ernesto, McLeod, Rima, Prigge, Sean T.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953223/
https://ncbi.nlm.nih.gov/pubmed/24295325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400945y
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