Damnacanthal, an effective inhibitor of LIM-kinase, inhibits cell migration and invasion

LIM-kinases (LIMKs) play crucial roles in various cell activities, including migration, division, and morphogenesis, by phosphorylating and inactivating cofilin. Using a bimolecular fluorescence complementation assay to detect the actin–cofilin interaction, we screened LIMK1 inhibitors and identifie...

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Huvudupphovsmän: Ohashi, Kazumasa, Sampei, Kaori, Nakagawa, Mami, Uchiumi, Naoto, Amanuma, Tatsuya, Aiba, Setsuya, Oikawa, Masato, Mizuno, Kensaku
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Cell Biology 2014
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952852/
https://ncbi.nlm.nih.gov/pubmed/24478456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-09-0540
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