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LIM Kinase Has a Dual Role in Regulating Lamellipodium Extension by Decelerating the Rate of Actin Retrograde Flow and the Rate of Actin Polymerization

Lamellipodium extension is crucial for cell migration and spreading. The rate of lamellipodium extension is determined by the balance between the rate of actin polymerization and the rate of actin retrograde flow. LIM kinase 1 (LIMK1) regulates actin dynamics by phosphorylating and inactivating cofi...

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Bibliografiske detaljer
Main Authors: Ohashi, Kazumasa, Fujiwara, Sachiko, Watanabe, Takuya, Kondo, Hiroshi, Kiuchi, Tai, Sato, Masaaki, Mizuno, Kensaku
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3196069/
https://ncbi.nlm.nih.gov/pubmed/21868383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.259135
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