A transcriptional silencer controls the developmental expression of the CD4 gene.

The appropriate expression of the CD4 glycoprotein is required for T-cell function and development. Here we define the transcriptional control elements in the CD4 locus that convey CD(4+)-specific expression of a marker gene in transgenic mice. Using nuclear run-on experiments, we have determined th...

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Bibliographic Details
Main Authors: Siu, G, Wurster, A L, Duncan, D D, Soliman, T M, Hedrick, S M
Format: Artigo
Language:Inglês
Published: 1994
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC395261/
https://ncbi.nlm.nih.gov/pubmed/8062832
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