PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8+ T cells induced by melanoma vaccines

Although melanoma vaccines stimulate tumor antigen (TA)-specific CD8+ T cells, objective clinical responses are rarely observed. To investigate this discrepancy, we evaluated the character of vaccine-induced CD8+ T cells with regard to the inhibitory T cell co-receptors PD-1 and Tim-3 in metastatic...

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Main Authors: Fourcade, Julien, Sun, Zhaojun, Pagliano, Ornella, Chauvin, Joe-Marc, Sander, Cindy, Janjic, Bratislav, Tarhini, Ahmad A., Tawbi, Hussein A., Kirkwood, John M., Moschos, Stergios, Wang, Hong, Guillaume, Philippe, Luescher, Immanuel F., Krieg, Arthur, Anderson, Ana C., Kuchroo, Vijay K., Zarour, Hassane M.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952491/
https://ncbi.nlm.nih.gov/pubmed/24343228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2908
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