Cell of origin in AML: Susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex

Pathways defining susceptibility of normal cells to oncogenic transformation may be valuable therapeutic targets. We characterized the cell of origin and its critical pathways in MN1-induced leukemias. Common myeloid (CMP), but not granulocyte-macrophage progenitors (GMP) could be transformed by MN1...

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Hauptverfasser: Heuser, Michael, Yun, Haiyang, Berg, Tobias, Yung, Eric, Argiropoulos, Bob, Kuchenbauer, Florian, Park, Gyeongsin, Hamwi, Iyas, Palmqvist, Lars, Lai, Courteney K., Leung, Malina, Lin, Grace, Chaturvedi, Anuhar, Thakur, Basant Kumar, Iwasaki, Masayuki, Bilenky, Mikhail, Thiessen, Nina, Robertson, Gordon, Hirst, Martin, Kent, David, Wilson, Nicola K., Göttgens, Bertie, Eaves, Connie, Cleary, Michael L., Marra, Marco, Ganser, Arnold, Humphries, R. Keith
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951989/
https://ncbi.nlm.nih.gov/pubmed/21741595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.06.020
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